Stanford
Reiter Lab Translational Cancer Evolution Laboratory

Publications

See profiles at Google Scholar, NIH, publons, and ORCiD.

Selected peer-reviewed publications

  1. Avanzini S, Kurtz DM, Chabon JJ, Moding EJ, Hori SS, Gambhir SS, Alizadeh AA, Diehn M, Reiter JG. A mathematical model of ctDNA shedding predicts tumor detection size. Science Advances 6, eabc4308
    2020 | PDF| Featured by: genomeweb
  2. Reiter JG*#, Hung W-T*, Lee I-H, Nagpal S, Giunta P, Degner S, Liu G, Wassenaar ECE, Jeck WR, Taylor MS, Farahani AA, Marble HD, Knott S, Kranenburg O, Lennerz JK, Naxerova K#. Lymph Node Metastases Develop Through a Wider Evolutionary Bottleneck Than Distant Metastases. Nature Genetics 52, 692-700
    2020 | PDF
    Featured by: Nature Genetics News and Views by T.A. Graham and D. Shibata, Faculty Opinions, Massachusetts General Hospital, Austrian Press Agency
  3. JG Reiter#, M Baretti, JM Gerold, AP Makohon-Moore, A Daud, CA Iacobuzio-Donahue, NS Azad, KW Kinzler, MA Nowak#, B Vogelstein#. An analysis of genetic heterogeneity in untreated cancers. Nature Reviews Cancer 19, 639-650
    2019 | PDF | Featured on the issue cover
  4. JG Reiter*#, AP Makohon-Moore*, JM Gerold*, A Heyde, MA Attiyeh, ZA Kohutek, CJ Tokheim, A Brown, RM DeBlasio, J Niyazov, A Zucker, R Karchin, KW Kinzler, CA Iacobuzio-Donahue, B Vogelstein, MA Nowak#. Minimal functional driver gene heterogeneity among untreated metastases. Science 361, 1033-1037
    2018 | PDF | full text |video
    (Bert Vogelstein, Johns Hopkins Kimmel Cancer Center)
    Featured by: NIH, Stanford Medicine, Harvard Gazette, Johns Hopkins, Cancer Discovery, cancer today, statnews, science.orf.at, Standard
  5. AP Makohon-Moore*, K Matsukuma*, M Zhang*, JG Reiter*, JM Gerold*, Y Jiao, L Sikkema, M Attiyeh, S Yachida, C Sandone, RH Hruban, DS Klimstra, N Papadopolous, MA Nowak, KW Kinzler, B Vogelstein, CA Iacobuzio-Donahue#. Precancerous neoplastic cells can move through the pancreatic ductal system. Nature 561, 201-205 2018 | PDF

    Featured by: Memorial Sloan Kettering, Cancer Discovery
  6. JG Reiter#, AP Makohon-Moore, JM Gerold, I Bozic, K Chatterjee, CA Iacobuzio-Donahue, B Vogelstein, MA Nowak#. Reconstructing metastatic seeding patterns of human cancers. Nature Communications 8, 14114
    2017 | PDF software

    Recommended by: F1000
  7. I Bozic*, JG Reiter*, B Allen*, T Antal, K Chatterjee, P Shah, YS Moon, A Yaqubie, N Kelly, DT Le, EJ Lipson, PB Chapman, LA Diaz, B Vogelstein, MA Nowak#. Evolutionary dynamics of cancer in response to targeted combination therapy. eLife 2:e00747
    2013 | PDF

    Featured by: Nature News and Views, New York Times, Nature Reviews Clinical Oncology, Science Translational Medicine, Boston Globe, F1000, Wiener Zeitung, Salzburger Nachrichten, science.orf.at

[* equal contribution] [# corresponding author] [lab members in bold font]

Preprints

  1. Avanzini S, Kurtz DM, Chabon JJ, Moding EJ, Hori SS, Gambhir SS, Alizadeh AA, Diehn M, Reiter JG#. A mathematical model of ctDNA shedding predicts tumor detection size. bioRxiv
    2020 | PDF
  2. JG Reiter#, S Nagpal, K Naxerova#. Lymphatic metastases have more diverse roots than distant metastases. bioRxiv 116, 14129-14137
    2019 | PDF
  3. H Sakamoto*, MA Attiyeh*, JM Gerold*, AP Makohon-Moore, A Hayashi, J Hong, R Kappagantula, L Zhang, J Melchor, JG Reiter, A Heyde, CM Bielski, A Penson, D Chakravarty, EM O’Reilly, LD Wood, RH Hruban, MA Nowak, ND Socci, BS Taylor, CA Iacobuzio-Donahue. Evolutionary Origins of Recurrent Pancreatic Cancer. bioRxiv
    2019 | PDF

[* equal contribution] [# corresponding author] [lab members in bold font]

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Publications

  1. Heyde A, Rohde D, McAlpine CS, Zhang S, Hoyer FF, Gerold JM, Cheek D, Iwamoto Y, Schloss MJ, Vandoorne K, Iborra-Egea, Munoz-Guijose C, Bayes-Genis A, Reiter JG, Craig M, Swirski FK, Nahrendorf M, Nowak MA, Naxerova K#. Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis. Cell 184, 1248-1361 2021 | Featured by: Cell Preview by A.J. Lusis
  2. Avanzini S, Kurtz DM, Chabon JJ, Moding EJ, Hori SS, Gambhir SS, Alizadeh AA, Diehn M, Reiter JG#. A mathematical model of ctDNA shedding predicts tumor detection size. Science Advances 6, eabc4308 2020 | PDF | Featured by: genomeweb
  3. Fujikura K, Hosoda W, Felsenstein M, Song Q, Reiter JG, Zheng L, Beleva Guthrie V, Rincon N, Dal Molin M, Dudley J, Cohen JD, Wang P, Fischer CG, Braxton AM, Noë M, Jongepier M, Fernández-Del Castillo C, Mino-Kenudson M, Schmidt CM, Yip-Schneider MT, Lawlor RT, Salvia R, Roberts NJ, Thompson ED, Karchin R, Lennon AM, Jiao Y, Wood LD#. Multiregion whole-exome sequencing of intraductal papillary mucinous neoplasms reveals frequent somatic KLF4 mutations predominantly in low-grade regions. Gut 2020
  4. Reiter JG*#, Hung W-T*, Lee I-H, Nagpal S, Giunta P, Degner S, Liu G, Wassenaar ECE, Jeck WR, Taylor MS, Farahani AA, Marble HD, Knott S, Kranenburg O, Lennerz JK, Naxerova K#. Lymph Node Metastases Develop Through a Wider Evolutionary Bottleneck Than Distant Metastases. Nature Genetics 52, 692-700
    2020 | PDF

    Featured by: Nature Genetics News and Views by T.A. Graham and D. Shibata, Faculty Opinions, Massachusetts General Hospital, Austrian Press Agency
  5. Sakamoto* H, Attiyeh* MA, Gerold* JM, Makohon-Moore AP, Hayashi A, Hong J, Kappagantula R, Zhang L, Melchor JP, Reiter JG, Heyde A, Bielski CM, Penson AV, Gonen M, Chakravarty D, O'Reilly EM, Wood LD, Hruban RH, Nowak MA, Socci ND, Taylor BS, Iacobuzio-Donahue# CA. The Evolutionary Origins of Recurrent Pancreatic Cancer. Cancer Discovery 10, 792-805 2020
    Featured by: Cancer Discovery Spotlight by F. Bednar and M. P. di Magliano, Nat Rev Gastro Hepat News and Views by I. Y. Xie and S. Gallinger
  6. Avanzini S, Kurtz DM, Chabon JJ, Hori SS, Alizadeh AA, Diehn M, Reiter JG#. ctDNA shedding dynamics dictate early lung cancer detection potential. Clinical Cancer Research 26, Supplement pp PR01 2020
  7. Ediriwickrema* A, Aleshin* A, Reiter JG, Corces MR, Köhnke T, Stafford M, Liedtke M, Medeiros BC, Majeti# R. Single-cell mutational profiling enhances the clinical evaluation of AML MRD. Blood Advances 4, 943–952 2020 | PDF
  8. JG Reiter#, M Baretti, JM Gerold, AP Makohon-Moore, A Daud, CA Iacobuzio-Donahue, NS Azad, KW Kinzler, MA Nowak#, B Vogelstein#. An analysis of genetic heterogeneity in untreated cancers. Nature Reviews Cancer 19, 639-650
    2019 | PDF | Featured on the issue cover
  9. A Heyde#, JG Reiter, K Naxerova, MA Nowak#. Consecutive seeding and transfer of genetic diversity in metastasis. Proc Natl Acad Sci USA 116, 14129-14137
    2019
  10. Gruber M*, Bozic I*, Leshchiner I*, Livitz D*, Stevenson K, Rassenti L, Rosebrock D, Taylor-Weiner A, Olive O, Goyetche R, Fernandes SM, Sun J, Stewart C, Wong A, Cibulskis C, Zhang W, Reiter JG, Gerold JM, Gribben JG, Rai KR, Keating MJ, Brown JR, Neuberg D, Kipps TJ, Nowak MA, Getz G#, Wu CJ#. Growth dynamics in naturally progressing chronic lymphocytic leukaemia. Nature 570, 474-479
    2019 | PDF
  11. JL Caswell-Jin, K McNamara, JG Reiter*, R Sun*, Z Hu, Z Ma, J Ding, CJ Suarez, S Tilk, A Raghavendra, V Forte, S Chin, H Bardwell, E Provenzano, C Caldas, J Lang, R West, D Tripathy, MF Press, C Curtis#. Clonal replacement and heterogeneity in breast tumors treated with neo‑adjuvant HER2-targeted therapy. Nature Communications 10, 657
    2019 | PDF
  12. JG Reiter*#, AP Makohon-Moore*, JM Gerold*, A Heyde, MA Attiyeh, ZA Kohutek, CJ Tokheim, A Brown, RM DeBlasio, J Niyazov, A Zucker, R Karchin, KW Kinzler, CA Iacobuzio-Donahue, B Vogelstein, MA Nowak#. Minimal functional driver gene heterogeneity among untreated metastases. Science 361, 1033-1037
    2018 | PDF | full text |video
    (Bert Vogelstein, Johns Hopkins Kimmel Cancer Center)
    Featured by: NIH, Stanford Medicine, Harvard Gazette, Johns Hopkins, Cancer Discovery, cancer today, statnews, science.orf.at, Standard
  13. AP Makohon-Moore*, K Matsukuma*, M Zhang*, JG Reiter*, JM Gerold*, Y Jiao, L Sikkema, M Attiyeh, S Yachida, C Sandone, RH Hruban, DS Klimstra, N Papadopolous, MA Nowak, KW Kinzler, B Vogelstein, CA Iacobuzio-Donahue#. Precancerous neoplastic cells can move through the pancreatic ductal system. Nature 561, 201-205
    2018 | PDF

    Featured by: Memorial Sloan Kettering, Cancer Discovery
  14. JG Reiter*, C Hilbe*, DG Rand, K Chatterjee, MA Nowak#. Crosstalk in concurrent repeated games impedes direct reciprocity and requires stronger levels of forgiveness. Nature Communications 9, 555
    2018 | PDF

    Featured by: science.orf.at, Standard
  15. K Naxerova#, JG Reiter, E Brachtel, J Lennerz, M Van de Wetering, A Rowan, T Cai, H Clevers, C Swanton, MA Nowak, SJ Elledge, RK Jain. Origins of lymphatic and distant metastases in human colorectal cancer. Science 357, 55-60
    2017

    Featured by: Science, n-tv, Standard
  16. E Vakiani#, RH Shah, MF Berger, AP Makohon-Moore, JG Reiter, I Ostrovnaya, MA Attiyeh, A Cercek, J Shia, CA Iacobuzio-Donahue, DB Solit, MR Weiser. Local recurrences at the anastomotic area are clonally related to the primary tumor in sporadic colorectal carcinoma. Oncotarget
    2017 | PDF
  17. JG Reiter#, AP Makohon-Moore, JM Gerold, I Bozic, K Chatterjee, CA Iacobuzio-Donahue, B Vogelstein, MA Nowak#. Reconstructing metastatic seeding patterns of human cancers. Nature Communications 8, 14114
    2017 | PDF software

    Recommended by: F1000
  18. AP Makohon-Moore*, M Zhang*, JG Reiter*, I Bozic, B Allen, D Kundu, K Chatterjee, F Wong, Y Jiao, ZA Kohutek, J Hong, B McMahon, LD Wood, RH Hruban, MA Nowak, N Papadopoulos, KW Kinzler, B Vogelstein, CA Iacobuzio-Donahue#. Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer. Nature Genetics 49, 358-366
    2017 | PDF software

    Featured by: Nature Reviews Cancer, Science Translational Medicine, Nature Genetics News and Views by C.R. Vakoc and D.A. Tuveson, Cancer Cell
  19. JG Reiter, CA Iacobuzio-Donahue#. Pancreatic carcinogenesis — several small steps or one giant leap? Nature Reviews Gastroeneterology and Hepatology 14, 7-8 2017 | PDF
  20. JG Reiter, AP Makohon-Moore, JM Gerold, I Bozic, K Chatterjee, CA Iacobuzio-Donahue, B Vogelstein, MA Nowak. Reconstructing the evolutionary history of metastatic cancers. Cancer Research 76(14):2374
    2016 | software
  21. DA Landau, E Tausch, AN Taylor-Weiner, C Stewart, JG Reiter, J Bahlo, S Kluth, I Bozic, M Lawrence, S Bottcher, SL Carter, K Cibulskis, D Mertens, C Sougnez, M Rosenberg, JM Hess, J Edelmann, S Kless, M Kneba, M Ritgen, A Fink, K Fischer, S Gabriel, ES Lander, MA Nowak, H Dohner, M Hallek, D Neuberg, G Getz#, S Stilgenbauer#, CJ Wu#. Mutations driving CLL and their evolution in progression and relapse. Nature 526, 525-530
    2015 | PDF
  22. JG Reiter#, A Kanodia, R Gupta, MA Nowak, K Chatterjee. Biological auctions with multiple rewards. Proceedings of the Royal Society B 282(1812):20151041
    2015 | PDF

    Featured by: die Presse, science.orf.at
  23. AP Makohon-Moore, M Zhang, JG Reiter, I Bozic, F Wong, Y Jiao, K Chatterjee, MA Nowak, N Papadopoulos, B Vogelstein, KW Kinzler, CA Iacobuzio-Donahue. Clonal evolution defines the natural history of metastatic pancreatic cancer. Cancer Research 75(15):4137
    2015
  24. DA Landau, C Stewart, JG Reiter, M Lawrence, C Sougnez, JR Brown, A Lopez-Guillermo, S Gabriel, E Lander, DS Neuberg, C Lopez-Otin, E Campo, G Getz, CJ Wu. Novel putative driver gene mutations in chronic lymphocytic leukemia (CLL): Results from a combined analysis of whole-exome sequencing of 262 primary CLL samples. Blood 124(21):1952
    2014
  25. BM Zagorsky*, JG Reiter*, K Chatterjee, MA Nowak#. Forgiver triumphs in alternating Prisoner's Dilemma. PLoS ONE 8(12):e80814
    2013 | PDF

    Featured by: Tiroler Tageszeitung, science.orf.at
  26. JG Reiter, I Bozic, K Chatterjee, MA Nowak. TTP: Tool for tumor progression. In Proceedings of 25th Int. Conf. on Computer Aided Verification, Lecture Notes in Computer Science 8044, 101-106
    2013 | PDF software website
  27. I Bozic*, JG Reiter*, B Allen*, T Antal, K Chatterjee, P Shah, YS Moon, A Yaqubie, N Kelly, DT Le, EJ Lipson, PB Chapman, LA Diaz, B Vogelstein, MA Nowak#. Evolutionary dynamics of cancer in response to targeted combination therapy. eLife 2:e00747
    2013 | PDF

    Featured by: Nature News and Views, New York Times, Nature Reviews Clinical Oncology, Science Translational Medicine, Boston Globe, F1000, Wiener Zeitung, Salzburger Nachrichten, science.orf.at
  28. JG Reiter*, I Bozic*, B Allen, K Chatterjee, MA Nowak#. The effect of one additional driver mutation on tumor progression. Evolutionary Applications 6, 34-45
    2013 | PDF software website
  29. LA Diaz#, R Williams, J Wu, I Kinde, JR Hecht, J Berlin, B Allen, I Bozic, JG Reiter, MA Nowak, KW Kinzler, KS Oliner#, B Vogelstein. The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature 486, 537-540
    2012 | PDF
    Nature News and Views: E Vilar, J Tabernero. Cancer: Pinprick diagnostics. Nature 486, 482-483
    2012
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    Featured by: Science, Nature News and Views, Nature Reviews Clinical Oncology, cancernetwork, F1000, science.orf.at, derStandard.at, Kleine Zeitung
  30. K Chatterjee*#, JG Reiter*, MA Nowak#. Evolutionary dynamics of biological auctions. Theoretical Population Biology 81, 69-80
    2012 | PDF

[* equal contribution] [# corresponding author] [lab members in bold font]