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cancer evolution


Putting circulating tumor DNA into a mechanistic framework

December 11, 2020

We developed a stochastic mathematical framework to study tumor growth and circulating tumor DNA (ctDNA) shedding to predict the potential and limitations of ctDNA for cancer early detection. We found that ctDNA can detect tumors earlier with higher specificity than other methods. The framework will help to accelerate clinical trials by identifying the most promising cancer early detection strategies. Read the full study in Science Advances.

Analyzing metastatic spread through a forest of phylogenies

May 25, 2020

In our new study, we developed a mathematical framework to analyze cancer phylogenies. In collaboration with the lab of Kamila Naxerova, we found that lymphatic and distant mets spread very differently and exhibit very different levels of heterogeneity. Nature Genetics article PDF

New study on ctDNA-based cancer early detection via liquid biopsies

February 14, 2020

We developed a mathematical model of cancer evolution and ctDNA shedding to predict the tumor detection size across different screening strategies with liquid biopsies. Available as a preprint: A mathematical model of ctDNA shedding predicts tumor detection size. bioRxiv
Johannes Reiter

Presented ctDNA model at AACR Special Conference Advances in Liquid Biopsies

January 14, 2020

We presented our newest results on ctDNA-based cancer early detection in a plenary talk at the AACR Special Conference Advances in Liquid Biopsies during the Plenary Session 1: Early Detection with ctDNA on Tuesday, January 14, 2020 in Miami. We also present a poster at the Poster Session A.

Received ASciNA Young Scientist Award 2019

September 14, 2019

Johannes Reiter received together with Hannes Mikula the ASciNA Young Scientist Award from the Austrian Federal Minister of Education, Science and Research Dr. Iris Eliisa Rauskala during the Austrian Research and Innovation Talk 2019 Science meets Business organized by the Office of Science and Technology Austria in Washington, DC. The selection of the awardees was conducted through a peer review process of the Austrian Science Fund (FWF).
Austrian Science Fund Austrian Press Agency Wiener Zeitung

Homogeneity of predicted functional mutations in driver genes

August 27, 2019

In a reanalysis of intratumoral heterogeneity in untreated cancers featured on the cover of Nature Reviews Cancer, we find that homogeneity of predicted functional mutations in driver genes is the rule rather than the exception. We also show that in most patients a single biopsy of a primary tumor captures the information necessary for initial therapeutic decision making. Nature Reviews Cancer article PDF

Consecutive seeding of metastases

June 29, 2019

In a new study of breast, colorectal, and ovarian cancer we find that some polyclonal metastases can be consecutively seeded dozens of times. PNAS article

Honored with Wissen schaf[f]t Zukunft Award

October 10, 2018

Johannes Reiter is honored with the Wissen schaf[f]t Zukunft Award by Lower Austria. news article

NIH features new study on minimal functional driver gene mutation heterogeneity

September 25, 2018

NIH Research Matters features our study on the Minimal functional driver gene heterogeneity among untreated metastases in Science. NIH article

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